Don't leave your programs running
Some programs will develop issues if you leave them open such as QuickBooks. Not to mention Word Documents Excel Spreadsheets etc.. It is always a best practice to exit and restart your computer at the end of the day. Doing this achieves two important tasks, one it logs you out and second, it makes sure all running applications are terminated.
The last thing you want is to find your critical data was not backed up because it was in use and you have now lost months of work.
Remember! reboot your computer at the end of the day to keep everything running well. Do not turn it off as security scans and patches are usually done after hours so as to not interfere with you while you work.